Group | HAT | Species | Function | Substrates | |
---|---|---|---|---|---|
Histone | Transcription factors | ||||
GNAT | Gcn5 | Yeast to Human | Transcriptional coactivator | + | + |
PCAF | Human | Transcriptional coactivator | + | + | |
Hat1 | Yeast to Human | 遺伝子発現抑制 | + | ||
Elp3 | Yeast to Human | 転写伸長反応 | + | ||
Hpa2 | Yeast | unknown | + | ||
MYST | Sas2 | Yeast | Silencing | + | |
Sas3 | Yeast | Silencing | + | ||
Esa1 | Yeast | Cell cycle regulation | + | ||
MOF | Drosophila | 遺伝子量補正 | + | ||
Tip60 | Human | Apoptosis, DNA修復 | + | + | |
MOZ | Human | Transcriptional activation | + | + | |
MORF | Human | Transcriptional activation | + | ||
HBO1 | Human | DNA修復, 転写開始 | + | ||
p300/CBP | p300 | Mouse, Rat, Human | Transcriptional activation | + | + |
CBP | C. elegans to Human | Transcriptional activation | + | + | |
Nuclear receptors | SRC-1 | Mouse, Human | Transcriptional activation | + | |
ACTR | Mouse, Human | Transcriptional activation | + | ||
TIF2 | Mouse, Human | Transcriptional activation | + | ||
Transcription factors | TAFII250 | Yeast to Human | Transcription factor, TBP-binding factor | + | |
TFIIIC | Human | Transcription factor | + | ||
Nut1 | Yeast to Human | Transcription factor | + |
Sterner DE, Berger SL. Acetylation of histones and transcription-related factors. Microbiol Mol Biol Rev. 2000; 64: 435-59.
Marmorstein R, Roth SY. Histone acetyltransferases: function, structure, and catalysis. Curr Opin Genet Dev. 2001; 11: 155-61.
Roth SY, Denu JM, Allis CD. Histone acetyltransferases. Annu Rev Biochem. 2001; 70: 81-120.